Cell / Biodynamics Simulation Project KYOTO UNIVERSITY
Project Outline
Myocardial (Cardiac Muscle) Cell Simulator
Simulator for a pancreatic Beta Cell
Project Team
Strategy for the Development of the Simulator

November 12 - 13, 2007
4th International Symposium of Cell/Biodynamics Simulation Project, Kyoto University

Symposium Site : Kyoto University, Shiran Kaikan, Inamori Hall
                (Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan )
Registration Fee : Free
Welcome Party : Monday,12 November

Invited Lecture : (Tentative)
   Kirsten ten Tusscher (Utrecht University, Utrecht The Netherlands)
   Albertas I. Undrovinas (Henry Ford Hospital, Detroit USA)
   Robert D. Harvey (Case Western Reserve University, Cleveland USA)
   Kazuhiro Aoki (kyoto University, Japan)
   Leon Axel (New York University Medical Center, New York USA)
   Shu Takagi (University of Tokyo, Japan)
   Leonid Livshitz (Washington University, St. Louis USA)
   Keiko Yanagi(ishihara) (Saga University, Japan)
   Yoshiri Sohma (Osaka Medical College, Japan)
   James B. Bassingthwaighte (University of Washington, Seattle USA)
   Do Han Kim (Gwangju Institute of Science and Technology, Gwangju Korea)


Ayako Takeuchi, Shuji Tatsumi, Nobuaki Sarai, Keisuke Terashima, Satoshi Matsuoka, and Akinori Noma, Ionic Mechanisms of Cardiac Cell Swelling Induced by Blocking Na+/K+ Pump As Revealed by Experiments and Simulation. The Journal of General Physiology, 128(5): 495-507, 2006. doi:10.1085/jgp.200609646

Commentary was also published as; Clive M. Baumgarten, Cell Volume Regulation in Cardiac Myocytes: A Leaky Boat Gets a New Bilge Pump. The Journal of General Physiology, 128(5): 495-507, 2006. doi:10.1085/jgp.200609679

We are working hard to publish the source code to reproduce the figures in Takeuchi et al. (2006), which will be available at sim-bio.org in a few weeks.

Examples of Biosimulator Application 1.Tailor-made Medical Care
The established simulation system will be of great help for medical doctors to decide the effective dosage of a drug or the appropriate therapy, to predict the disease state and to develop a treatment plan for an individual patient while applying patient specific medical and genomic information to the biosimulator.
2.Promotion of Efficiency in Drug Development and Avoidence of Phytotoxicity
The biosimulator may be fed with information of pharmacological experiments and thus assist in efficacy and side effect predictions of new drugs.
Project Outline
Myocardial (Cardiac Muscle) Cell Simulator Simulation of a Pancreatic Beta Cell
Using the Kyoto Model, conditions of acute heart diseases like myocardial cell ischemia, myocardial infarction or the digitalis effect can be simulated.
Myocardial (Cardiac Muscle) Cell Simulator
This simulation program may be used to show the fluctuation of the membrane potential etc. of a pancreatic beta cell.

Simulation of a Pancreatic Beta Cell
Last modified February 27 2004. © 2002 - 2004, Kyoto University All rights Reserved.